Atlas SonoLab benefits
Selective: Significantly improved polymorph, particle size and particle shape selectivity.
Narrow particle size distribution: Advanced control of nucleation and growth rate results in very narrow particle size distribution.
High purity: Sophisticated control results in reduced
impurities and trapped solvents.
Reproducible: Automated control of process
parameters and nucleation improves batch to batch
consistency.
Scalable: Optimised crystallizations on a laboratory
scale can be scaled to pilot plant processes and
manufacturing using the Prosonitron™ range of
products from Prosonix Ltd.
Product quality improvement: Improved formulation
consistency, stability and performance of final drug
products.
No seeding required: Removing the need for seed
crystals avoids issues with consistency and access to
the reactor.
Easy to use: No tools required, intuitive “drag and drop”
Atlas software and real time data graphed during
process.
Excellent temperature control: Sophisticated PID
temperature control and accurate sensor feedback
results in accurate process performance.
Advanced automation: With the Atlas PC software,
the system can introduce ultrasound at accurate
temperature points within and around the metastable
zone.
Integrated turbidity or FBRM analysis: The Atlas
Software allows integration of the Syrris Turbidity Probe
or FBRM characterization.
What is Sonocrystallization?
Sonocrystallization is the application of high intensity, low frequency ultrasound to your process, resulting in acoustic cavitation of the solution. Controlled cavitation allows extremely accurate control of nucleation, a process which is random and very difficult to control by conventional techniques.
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The Atlas SonoLab system is based on Syrris’ Atlas Potassium System for jacketed vessels with the addition of the Prosonix proprietary ultrasonic flow cell, generator and pump.
The powerful Atlas Software allows full control of all the important parameters required for sonocrystallization, sonomilling and sonochemistry applications:
Crystallization
- Automated metastable zone width studies
- Optimisation of product recovery - crystal size,
purity and recovery
- Complete control of crystallization using pulsed or
continuous insonation
Scale-up
- Batch-to-batch repeatability
- Seamless scale to pilot plant and beyond using
Prosonitron™
Polymorphism
- Impact of different solvents, mixtures,
concentrations and temperatures
- Selective polymorph control without seeding
Milling Studies
- Removal of conventional wet milling steps
- Reduced fines compared to wet milling
An Atlas SonoLab System contains:
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